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74784-70-6

  • Product Name5-(Trifluoromethyl)pyridin-2-amine
  • Molecular FormulaC6H5F3N2
  • Molecular Weight162.114
  • Purity99%
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  • CasNo： 74784-70-6
  • Molecular Formula： C6H5F3N2
  • Purity： 99%

Quality Factory Supply Top Purity 5-(Trifluoromethyl)pyridin-2-amine 74784-70-6 with Efficient Delivery 

  • Molecular Formula:C6H5F3N2
  • Molecular Weight:162.114
  • Vapor Pressure:0.217mmHg at 25°C 
  • Melting Point:45 °C 
  • Refractive Index:1,533 
  • Boiling Point:208.2 °C at 760 mmHg 
  • PKA:4.55±0.13(Predicted) 
  • Flash Point:79.7 °C 
  • PSA：38.91000 
  • Density:1.368 g/cm3 
  • LogP:2.26380 

5-(Trifluoromethyl)pyridin-2-amine(Cas 74784-70-6) Usage

Chemical Properties

White to brown solid

Uses

2-?Amino-?5-?(trifluoromethyl)? is a reagent used in the synthesis of selective inhibitors of urokinase plasminogen activator in a non-cytotoxic form of cancer therapy.

InChI:InChI=1/C6H5F3N2/c7-6(8,9)4-1-2-5(10)11-3-4/h1-3H,(H2,10,11)

74784-70-6 Relevant articles

PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS

-

Page/Page column 51; 54, (2017/04/11)

The present invention relates to a catal...

Aminoquinazolines as TRPV1 antagonists: Modulation of drug-like properties through the exploration of 2-position substitution

Blum, Charles A.,Zheng, Xiaozhang,Brielmann, Harry,Hodgetts, Kevin J.,Bakthavatchalam, Rajagopal,Chandrasekhar, Jayaraman,Krause, James E.,Cortright, Daniel,Matson, David,Crandall, Marci,Ngo, Chu K.,Fung, Lawrence,Day, Marta,Kershaw, Mark,De Lombaert, Stephane,Chenard, Bertrand L.

body text, p. 4573 - 4577 (2009/04/06)

A focused SAR exploration of the lead 4-...

SOME NEW 2-SUBSTITUTED 5-TRIFLUOROMETHYLPYRIDINES

Haga, Takahiro,Fujikawa, Kan-ichi,Koyanagi, Tohru,Nakajima, Toshio,Hayashi, Kouji

, p. 117 - 124 (2007/10/02)

The preparation of the derivatives of 2-...

74784-70-6 Process route

2-chloro-5-(Trichloromethyl)-pyridine
69045-78-9

2-chloro-5-(Trichloromethyl)-pyridine

2-amino-5-trifluoromethylpyridine
74784-70-6

2-amino-5-trifluoromethylpyridine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 54.5 percent / antimony trifluoride / 0.17 h / Heating
2: 39 percent / aq. ammonia / 8 h / 180 °C
With ammonium hydroxide; antimony(III) fluoride;
 
Multi-step reaction with 2 steps
1: 54.5 percent / antimony trifluoride / 0.17 h / Heating
2: 75 percent / aq. ammonia / 24 h / 135 °C
With ammonium hydroxide; antimony(III) fluoride;
 
isopropyl benzoate
939-48-0

isopropyl benzoate

2-amino-5-trifluoromethylpyridine
74784-70-6

2-amino-5-trifluoromethylpyridine

Conditions
Conditions Yield
With Zn(2+)*2C2H3O2(1-)*17H2O; at 75 ℃; for 6h;
3 %Chromat.

74784-70-6 Upstream products

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74784-70-6 Downstream products

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    5-(Trifluoromethyl)-3-nitro-2-aminopyridine

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