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137234-88-9

  • Product Name4-Ethyl-5-fluoropyridine
  • Molecular FormulaC6H7FN2
  • Molecular Weight126.133
  • Purity99%
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Product Details

Quick Details

  • CasNo： 137234-88-9
  • Molecular Formula： C6H7FN2
  • Purity： 99%

Quality Manufacturer Supply Wholesale 4-Ethyl-5-fluoropyridine 137234-88-9 In Stock

  • Molecular Formula:C6H7FN2
  • Molecular Weight:126.133
  • Vapor Pressure:4.45mmHg at 25°C 
  • Refractive Index:1.478 
  • Boiling Point:169.5 ºC at 760 mmHg 
  • PKA:0.95±0.16(Predicted) 
  • Flash Point:56.3 ºC 
  • PSA：25.78000 
  • Density:1.117 g/cm3 
  • LogP:1.17810 

4-Ethyl-5-fluoropyridine(Cas 137234-88-9) Usage

Uses

A Voriconazole (V760000) impurity.

InChI:InChI=1/C7H8FN/c1-2-6-3-4-9-5-7(6)8/h3-5H,2H2,1H3

137234-88-9 Relevant articles

Process development of voriconazole: A novel broad-spectrum triazole antifungal agent

Butters, Mike,Ebbs, Julie,Green, Stuart P.,MacRae, Julie,Morland, Matthew C.,Murtiashaw, Charles W.,Pettman, Alan J.

, p. 28 - 36 (2013/09/07)

In the synthesis of (2R,3S)-2-(2,4-diflu...

Triazole antifungal agents

-

, (2008/06/13)

The invention provide antifungal compoun...

137234-88-9 Process route

2,4-dichloro-6-ethyl-5-fluoropyrimidine
137234-85-6

2,4-dichloro-6-ethyl-5-fluoropyrimidine

4-ethyl-5-fluoropyrimidine
137234-88-9

4-ethyl-5-fluoropyrimidine

Conditions
Conditions Yield
With 5%-palladium/activated carbon; hydrogen; sodium acetate; In methanol; at 50 ℃; for 5h; under 2585.81 Torr;
35%
With sodium acetate; palladium; In methanol;
 
4-ethyl-5-fluoropyrimidine
137234-88-9

4-ethyl-5-fluoropyrimidine

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate
188416-34-4,137234-71-0

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sodium hexamethyldisilazane / tetrahydrofuran; toluene / -60 °C
2: methanol; acetone / Reflux
With sodium hexamethyldisilazane; In tetrahydrofuran; methanol; acetone; toluene;
 
Multi-step reaction with 3 steps
1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / dichloromethane / 6 h / Reflux
2: zinc; lead / tetrahydrofuran / 16 °C / Inert atmosphere; Reflux
3: methanol; acetone / Reflux
With lead; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); zinc; In tetrahydrofuran; methanol; dichloromethane; acetone;
 

137234-88-9 Upstream products

  • 137234-85-6
    137234-85-6

    2,4-dichloro-6-ethyl-5-fluoropyrimidine

137234-88-9 Downstream products

  • 137234-63-0
    137234-63-0

    2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

  • 137234-63-0
    137234-63-0

    2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butane-2-ol

  • 188416-34-4
    188416-34-4

    (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate

  • 137234-62-9
    137234-62-9

    voriconazole

;

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