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241479-73-2

  • Product Name1-(((2R,3S)-2-(2,5-difluorophenyl)-3-Methyloxiran-2-yl)Methyl)-1H-1,2,4-triazole
  • Molecular FormulaC12H11F2N3O
  • Molecular Weight251.236
  • Purity99%
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Product Details

Quick Details

  • CasNo： 241479-73-2
  • Molecular Formula： C12H11F2N3O
  • Purity： 99%

Trustworthy Manufacturer Supply Best Quality 1-(((2R,3S)-2-(2,5-difluorophenyl)-3-Methyloxiran-2-yl)Methyl)-1H-1,2,4-triazole 241479-73-2 with Efficient Delivery 

  • Molecular Formula:C12H11F2N3O
  • Molecular Weight:251.236
  • Boiling Point:386.5±52.0 °C(Predicted) 
  • PKA:2.75±0.10(Predicted) 
  • PSA：43.24000 
  • Density:1.41±0.1 g/cm3(Predicted) 
  • LogP:1.87050 

241479-73-2 Relevant articles

Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents

Feng, Xiaoming,He, Qianwen,Liu, Xiaohua,Zhang, Dong,Zhang, Fengcai

supporting information, p. 6961 - 6966 (2021/09/11)

An enantioselective epoxidation of α-sub...

PROCESS FOR PRODUCING EPOXY ALCOHOL COMPOUND

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Paragraph 0125, (2020/06/29)

A compound represented by formula (II): ...

Synthetic method for antifungal drug intermediate (2R,3S)-1-(1,2,4-triazol)-2-difluorophenyl-2,3-epoxybutane

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Paragraph 0016; 0022; 0028; 0034; 0040, (2016/10/07)

The invention discloses a synthetic meth...

A PROCESS FOR THE PREPARATION OF ISAVUCONAZOLE AND ITS INTERMEDIATES

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Page/Page column 15; 18; 19, (2015/11/17)

The present invention relates to a proce...

241479-73-2 Process route

(2R,3R)-2-(2,5-difluoro-phenyl)-1-(1H-1,2,4-triazole-1-yl)butan-2,3-diol
241479-72-1

(2R,3R)-2-(2,5-difluoro-phenyl)-1-(1H-1,2,4-triazole-1-yl)butan-2,3-diol

(2R,3S)-2-(2,5-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)-methyl]-oxirane
241479-73-2

(2R,3S)-2-(2,5-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)-methyl]-oxirane

Conditions
Conditions Yield
(2R,3R)-2-(2,5-difluoro-phenyl)-1-(1H-1,2,4-triazole-1-yl)butan-2,3-diol; With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.333333h;
With tetrabutylammomium bromide; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 12h; enantioselective reaction;
95%
With sodium methylate; triethylamine; In methanol; CH2Cl2-EtOAc; ethyl acetate; methanesulfonyl chloride;
88%
With tert-butyl methyl ether; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at -10 - 10 ℃; for 1h; Large scale;
85%
With methanesulfonyl chloride; triethylamine; In dichloromethane; at 10 - 25 ℃;
33.5 g
With methanesulfonyl chloride; triethylamine; at 0 - 3 ℃; for 3h;
5.94 g
(2R,3R)-2-(2,5-difluoro-phenyl)-1-(1H-1,2,4-triazole-1-yl)butan-2,3-diol
241479-72-1

(2R,3R)-2-(2,5-difluoro-phenyl)-1-(1H-1,2,4-triazole-1-yl)butan-2,3-diol

NaOMe methanol

NaOMe methanol

(2R,3S)-2-(2,5-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)-methyl]-oxirane
241479-73-2

(2R,3S)-2-(2,5-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)-methyl]-oxirane

Conditions
Conditions Yield
With triethylamine; In methanol; dichloromethane;
93%

241479-73-2 Upstream products

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    (R)-1-[(R)-2-(2,5-difluorophenyl)-2-oxiranyl]ethyl methanesulfonate

  • 241479-72-1
    241479-72-1

    (2R,3R)-2-(2,5-difluoro-phenyl)-1-(1H-1,2,4-triazole-1-yl)butan-2,3-diol

  • 288-88-0
    288-88-0

    1,2,4-Triazole

241479-73-2 Downstream products

  • 241479-74-3
    241479-74-3

    (2S,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butyronitrile

  • 329744-74-3
    329744-74-3

    (2R,3R)-2-(2,5-difluorophenyl)-3-[(trans-2-phenyl-1,3-dioxan-5-yl)thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol

  • 241479-67-4
    241479-67-4

    Isavuconazole

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