Your Location：Home >Products >API >69304-47-8

69304-47-8

  • Product NameBrivudine
  • Molecular FormulaC11H13BrN2O5
  • Molecular Weight333.139
  • Purity99%
Inquiry

Product Details

Quick Details

  • CasNo： 69304-47-8
  • Molecular Formula： C11H13BrN2O5
  • Purity： 99%

Chinese Manufacturer Supply  High Purity 99% Brivudine 69304-47-8 with Lowest Price

  • Molecular Formula:C11H13BrN2O5
  • Molecular Weight:333.139
  • Vapor Pressure:4.56E-06mmHg at 25°C 
  • Melting Point:165 °C 
  • Refractive Index:1.6520 (estimate) 
  • Boiling Point:382.9ºC at 760 mmHg 
  • PKA:8.37±0.10(Predicted) 
  • Flash Point:185.4ºC 
  • PSA：104.55000 
  • Density:1.857 g/cm3  
  • LogP:-0.45710 

Brivudine(Cas 69304-47-8) Usage

Description

(E)-5-(2-Bromovinyl)-2'-deoxyuridine is an thymidine analogue and acts as an anti-viral by inhibiting DNA plymerase.

Chemical Properties

White solid

Uses

It is used as pharmaceutical intermediate.

InChI:InChI=1/C13H17Cl3N4.2ClH/c1-20(5-2-14)8-9-6-10(15)12(11(16)7-9)19-13-17-3-4-18-13;;/h6-7H,2-5,8H2,1H3,(H2,17,18,19);2*1H

69304-47-8 Relevant articles

Syntheses of 5-(2-radiohaloethyl)- and 5-(2-radiohalovinyl)-2′-deoxyuridines. Novel types of radiotracer for monitoring cancer gene therapy with PET

Yu, Chung-Shan,Eisenbarth, Joseph,Runz, Armin,Weber, Klaus,Zeisler, Stephan,Oberdorfer, Franz

, p. 421 - 439 (2003)

Syntheses of 5-(2-[18F]fluoroethyl)- (1)...

Pd-imidate complexes as recyclable catalysts for the synthesis of C5-alkenylated pyrimidine nucleosides via Heck cross-coupling reaction

Ardhapure, Ajaykumar V.,Sanghvi, Yogesh S.,Kapdi, Anant R.,García, Joaquín,Sanchez, Gregorio,Lozano, Pedro,Serrano, J. Luis

, p. 24558 - 24563 (2015)

Pd-imidate complexes have been employed ...

Novel synthesis process of bromovudine and bromovudine

-

, (2021/08/11)

The invention discloses a novel synthesi...

ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites

Kandil, Sahar,Balzarini, Jan,Rat, Stephanie,Brancale, Andrea,Westwell, Andrew D.,McGuigan, Christopher

, p. 5618 - 5623 (2016/11/29)

Nucleosides represent a major chemothera...

A comparison between immobilized pyrimidine nucleoside phosphorylase from Bacillus subtilis and thymidine phosphorylase from Escherichia coli in the synthesis of 5-substituted pyrimidine 2′-deoxyribonucleosides

Serra, Immacolata,Bavaro, Teodora,Cecchini, Davide A.,Daly, Simona,Albertini, Alessandra M.,Terreni, Marco,Ubiali, Daniela

, p. 16 - 22 (2013/10/22)

Pyrimidine nucleoside phosphorylase from...

69304-47-8 Process route

2'-deoxyuridine
951-78-0,63844-76-8

2'-deoxyuridine

(E)-5-(2-bromovinyl)uracil
69304-49-0

(E)-5-(2-bromovinyl)uracil

uracil
66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6

uracil

(E)-5-(2-bromovinyl)-2'-deoxyuridine
69304-47-8

(E)-5-(2-bromovinyl)-2'-deoxyuridine

Conditions
Conditions Yield
With potassium carbonate; In aq. phosphate buffer; at 20 ℃; for 3h; pH=10; Reagent/catalyst; Enzymatic reaction;
 
(E)-3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylic acid
74131-06-9

(E)-3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylic acid

(E)-5-(2-bromovinyl)-2'-deoxyuridine
69304-47-8

(E)-5-(2-bromovinyl)-2'-deoxyuridine

Conditions
Conditions Yield
With N-Bromosuccinimide; In tetrahydrofuran; water; at 25 ℃; for 0.5h;
95%
(E)-3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylic acid; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;
With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
89%
(E)-3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylic acid; With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.25h;
With N-Bromosuccinimide; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;
71.9%
With N-Bromosuccinimide; 1-ethylene glycol monomethyl ether-3-methylimidazolium methanesulfonate; at 20 ℃; for 1h;
70%
With N-Bromosuccinimide; potassium carbonate; In N,N-dimethyl-formamide;
150 mg (67%)
With N-Bromosuccinimide; potassium carbonate;
 

69304-47-8 Upstream products

  • 85267-70-5
    85267-70-5

    3',5'-Di-O-acetyl-(Z)-5-<2-(trimethylsilyl)ethenyl>-2'-deoxyuridine

  • 871918-18-2
    871918-18-2

    5-(1-fluoro-2-bromoethyl)-3',5'-di-O-acetyl-2'-deoxyuridine

  • 73446-74-9
    73446-74-9

    (E)-5-(2-bromovinyl)-2'-deoxy-3',5'-di-O-(p-toluoyl)uridine

  • 74131-06-9
    74131-06-9

    (E)-3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylic acid

69304-47-8 Downstream products

  • 84218-85-9
    84218-85-9

    (E)-5-(2-bromovinyl)-2'-deoxy-5'-O-p-toluenesulphonyluridine

  • 114494-94-9
    114494-94-9

    (E)-5-(2-bromovinyl)-2'-deoxy-5'-O-t-butyldiphenylsilyluridine

  • 86214-06-4
    86214-06-4

    (E)-5-(2-bromovinyl)-2'-deoxy-3-methyluridine

  • 232925-18-7
    232925-18-7

    (E)-5-(2-bromovinyl)-2'-deoxy-5'-uridyl phenyl L-methoxyalaninylphosphoramidate

;

Relevant Products

Contact Now

Submit

Contact us

Address:3rd Building, Hua Yi Road 76 Zhangjiang Pudong New Area Shanghai

Tel:+86-13701882790

Phone:请录入手机号

QQ:请录入QQ

Email:sales@scochem.com

Maps

Home About us Products Amino acid Contact Us

links

Copyright @2009-2024 Shanghai Scochem Technology Co., Ltd ICP NO.:Zhejiang000000