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39065-95-7

  • Product Name4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE
  • Molecular FormulaC7H6ClF2NO
  • Molecular Weight193.581
  • Purity99%
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Product Details

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  • CasNo： 39065-95-7
  • Molecular Formula： C7H6ClF2NO
  • Purity： 99%

Reputable Manufacturer Supply Factory Sells 4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE 39065-95-7 with Competitive Price

  • Molecular Formula:C7H6ClF2NO
  • Molecular Weight:193.581
  • Vapor Pressure:0.0609mmHg at 25°C 
  • Refractive Index:1.525 
  • Boiling Point:231.9 °C at 760 mmHg 
  • PKA:4.04±0.10(Predicted) 
  • Flash Point:94 °C 
  • PSA：35.25000 
  • Density:1.402g/cm3 
  • LogP:3.01790 

4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE(Cas 39065-95-7) Usage

Uses

4-Chlorodifluoromethoxyaniline has been used as a reactant for the preparation of arylphthalazines as a potent and orally bioavailable inhibitor of VEGFR-2.

InChI:InChI=1/C7H6ClF2NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2

39065-95-7 Relevant articles

Synergistic effects in Fe nanoparticles doped with ppm levels of (Pd + Ni). A new catalyst for sustainable nitro group reductions

Pang, Haobo,Gallou, Fabrice,Sohn, Hyuntae,Camacho-Bunquin, Jeffrey,Delferro, Massimiliano,Lipshutz, Bruce H.

supporting information, p. 130 - 135 (2018/01/12)

A remarkable synergistic effect has been...

A 4 - ( chlorine two fluorine methoxy ) method for preparing aniline

-

Paragraph 0018; 0032; 0033; 0037; 0038, (2018/02/04)

The invention relates to a preparation m...

Hydrogenation on granular palladium-containing catalysts: II. Hydrogenation of nitroheterocyclic compounds

Kislyi,Tolkacheva,Semenov

, p. 269 - 271 (2007/10/03)

Nitroheterocyclic compounds were reduced...

39065-95-7 Process route

1-(chlorodifluoromethoxy)-4-nitrobenzene
40750-71-8

1-(chlorodifluoromethoxy)-4-nitrobenzene

4-[chloro(difluoro)methoxy]aniline
39065-95-7

4-[chloro(difluoro)methoxy]aniline

Conditions
Conditions Yield
With hydrogen; ShPAK-0.5; In methanol;
91%
With sodium tetrahydroborate; TPGS-750-M; In tetrahydrofuran; water; at 20 ℃; for 0.5h;
91%
With hydrogen; In ethyl acetate; at 30 - 40 ℃; for 1h; under 15001.5 - 22502.3 Torr; Temperature; Solvent; Autoclave;
64.2%
(trichloromethoxy)benzene
34888-05-6

(trichloromethoxy)benzene

4-[chloro(difluoro)methoxy]aniline
39065-95-7

4-[chloro(difluoro)methoxy]aniline

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: hydrogen fluoride; perfluorooctyl sulfofluorure / 4 h / 5 - 110 °C / 18751.9 - 21002.1 Torr / Autoclave
2: sulfuric acid; nitric acid / water / 15 - 20 °C
3: hydrogen / ethyl acetate / 1 h / 30 - 40 °C / 15001.5 - 22502.3 Torr / Autoclave
With perfluorooctyl sulfofluorure; sulfuric acid; hydrogen fluoride; hydrogen; nitric acid; In water; ethyl acetate;
 

39065-95-7 Upstream products

  • 40750-71-8
    40750-71-8

    1-(chlorodifluoromethoxy)-4-nitrobenzene

  • 34888-05-6
    34888-05-6

    (trichloromethoxy)benzene

39065-95-7 Downstream products

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    321596-13-8

    N-(4'-chlorodifluoromethoxyphenyl)-2,4,6-trinitrobenzamide

  • 866758-52-3
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    [4-(chlorodifluoromethoxy)phenyl]-(4-chlorophthalazin-1-yl)amine

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