Product Details
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Description |
Edetate calcium disodium is a metal ion chelator used to reduce blood concentrations and depot stores of lead from the body. It is on the World Health Organization Model List of Essential Medicines. |
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Uses |
Chelating agent (metal). |
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Brand name |
Calcium Disodium Versenate (3M Pharmaceuticals). |
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Pharmaceutical Applications |
Calcium disodium edetate, also referred to as calcium sodium EDTA, stands for the chemical compound 2,2 ,2 ,2 -(ethane-1,2-diyldinitrilo)tetraacetic acid, which is a synthetic amino acid. Edetate refers to the calcium disodium salt of the chelating agent with the formula (HO2CCH2)2NCH2CH2N(CH2CO2H)2. In the United States, it is found under the name calcium disodium versenate. Edetate is mainly used to complex di and trivalent metal ions. Edetate can bind to metals via the four carboxylate and two amine groups, and it forms specially strong complexes with Co(III), Cu(II), Mn(II) and Fe(III). Dimercaprol (BAL, British anti-Lewisite), calcium disodium edetate and penicillamine are the three most common chelating agents used in the treatment of heavy-metal poisoning. Treatment with calcium disodium EDTA improves symptoms of lead poisoning such as abdominal pain, fatigue, constipation, and loss of appetite. It also seems to slow progression of kidney failure in patients who have had long-term lead poisoning. |
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Who Evaluation |
Evaluation year: 1973 |
InChI:InChI=1/C10H16N2O8.Ca.2Na/c11-9(1-5(13)14,2-6(15)16)10(12,3-7(17)18)4-8(19)20;;;/h1-4,11-12H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4
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