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The invention discloses a preparation me...
The invention provides a novel preparati...
benzo[B]thiophen-4-ylamine
bis-(2-chloroethyl)amine hydrochloride
1-(benzo[b]thiophen-4-yl)piperazine hydrochloride
Conditions | Yield |
---|---|
With toluene-4-sulfonamide; In 5,5-dimethyl-1,3-cyclohexadiene; at 120 - 150 ℃; for 16h;
|
85% |
With potassium carbonate; In butan-1-ol; for 24h; Reflux;
|
84% |
1-(benzo[b]thiophen-4-yl)piperazine hydrochloride
7-(4-bromobutoxy-1,1,2,2,3,3,4,4-d8)-1H-quinolin-2-one
7-[4-(4-benzo[b]thiophen-4-ylpiperazin-1-yl)butoxy-1,1,2,2,3,3,4,4-d8]-1H-quinolin-2-one
Conditions | Yield |
---|---|
With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 6h;
|
0.3 g |
With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 6h;
|
0.3 g |
benzo[B]thiophen-4-ylamine
bis-(2-chloroethyl)amine hydrochloride
7-[4-(4-benzo[b]thiophen-4-ylpiperazin-1-yl)butoxy-1,1,2,2,3,3,4,4-d8]-1H-quinolin-2-one
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