What is the 6-Heptyn-1-ol?

6-Heptyn-1-ol is , while it's Molecular Formula is C7H12O. 6-Heptyn-1-ol is used as a reagent in in the preparation of many cyclic compounds. It is also used as a Intermediate in organic synthesis.

What is the CAS number for 6-Heptyn-1-ol?

The CAS number of 6-Heptyn-1-ol is 63478-76-2.

Trustworthy Factory Supply Top Purity 99% 6-Heptyn-1-ol 63478-76-2 with the Best Price

Product Details

Quick Details

CasNo： 63478-76-2
Molecular Formula： C₇H₁₂O
Purity： 99%

Trustworthy Factory Supply Top Purity 99% 6-Heptyn-1-ol 63478-76-2 with the Best Price

Molecular Formula:C7H12O
Molecular Weight:112.172
Vapor Pressure:0.378mmHg at 25°C
Melting Point:-20.62°C (estimate)
Refractive Index:1.452
Boiling Point:174.3 °C at 760 mmHg
PKA:15.14±0.10(Predicted)
Flash Point:92.8 °C
PSA：20.23000
Density:0.894 g/cm³
LogP:1.17230

6-Heptyn-1-ol(Cas 63478-76-2) Usage

Chemical Properties	6-Heptyn-1-ol is Pale Yellow Oil
Uses	6-Heptyn-1-ol reagents used in the preparation of many cyclic compounds.
Synthesis Reference(s)	The Journal of Organic Chemistry, 49, p. 5175, 1984 DOI: 10.1021/jo00200a032

InChI:InChI=1/C7H12O/c1-2-3-4-5-6-7-8/h1,8H,3-7H2

63478-76-2 Relevant articles

Polydiacetylene stabilized gold nanoparticles - extraordinary high stability and integration into a nanoelectrode device

Liffmann,Homberger,Mennicken,Karth?user,Simon

, p. 102981 - 102992 (2015)

A new diacetylene containing photopolyme...

Intramolecular silicon-assisted cross-coupling reactions: General synthesis of medium-sized rings containing a 1,3-cis-cis diene unit

Denmark, Scott E.,Yang, Shyh-Ming

, p. 2102 - 2103 (2002)

The combination of ring-closing metathes...

Total synthesis of two novel brominated acetylenic diols (+)-diplyne C and E: Stereoselective construction of the (E)-1-bromo-1-alkene

Gung, Benjamin W.,Gibeau, Craig,Jones, Amanda

, p. 3107 - 3114 (2005)

The total syntheses of the enantiomers o...

On the intramolecular pyrone Diels-Alder approach to basiliolide B

Kozytska, Mariya V.,Dudley, Gregory B.

, p. 2899 - 2901 (2008)

A unified synthetic approach to the basi...

Synthesis of brombyins II and III, cyclostachines A and B, and cyclopiperstachine, plant-derived octahydronaphthalenes

Lygo, Barry,Beaumont, Douglas J.,Cooke, Jason W.B.,Hirst, David J.

, p. 618 - 622 (2010)

In this paper we present a study into th...

Directed Regioselective Carbometallation of 1,2-Dialkyl-Substituted Cyclopropenes

Cohen, Yair,Marek, Ilan

supporting information, p. 26368 - 26372 (2021/11/10)

A regio- and diastereoselective copper-c...

Total Synthesis of a Mycolic Acid from Mycobacterium tuberculosis

Buter, Jeffrey,Fodran, Peter,Jayaraman, Dhineshkumar,Minnaard, Adriaan J.,Moody, D. Branch,Ocampo, Tonatiuh A.,Tahiri, Nabil,Van Rhijn, Ildiko,Witte, Martin D.

supporting information, p. 7555 - 7560 (2020/03/23)

In Mycobacterium tuberculosis, mycolic a...

Total Synthesis of the Tetrasubstituted Furan Fatty Acid Metabolite CeDFP via Au-Catalyzed Intermolecular Alkyne Hydroarylation

Wang, Yamin,Pritchard, Gareth J.,Kimber, Marc C.

supporting information, p. 4892 - 4895 (2019/06/27)

The first total synthesis of the tetrasu...

Synthesis and Evaluation of a Series of Bis(pentylpyridinium) Compounds as Antifungal Agents

Obando, Daniel,Koda, Yasuko,Pantarat, Namfon,Lev, Sophie,Zuo, Xiaoming,Bijosono Oei, Johanes,Widmer, Fred,Djordjevic, Julianne T.,Sorrell, Tania C.,Jolliffe, Katrina A.

, p. 1421 - 1436 (2018/07/29)

A series of bis(4-pentylpyridinium) comp...

63478-76-2 Process route

: 14916-79-1
3-heptyn-1-ol

: 63478-76-2
1-hydroxy-6-heptyne

Conditions

Conditions	Yield
With sodium hydride; Trimethylenediamine; at 20 ℃; for 0.666667h;	100%
With potassium tert-butylate; sodium hydride; Trimethylenediamine; In mineral oil; at 20 - 70 ℃; for 3h;	99%
With potassium tert-butylate; lithium; Trimethylenediamine; at 20 ℃; for 2h;	97%
With potassium hydride; Trimethylenediamine; at 20 ℃; Inert atmosphere;	97%
With sodium hydride; ethylenediamine; In mineral oil; at 10 ℃;	93%
With sodium amide; Trimethylenediamine; In various solvent(s); at 80 ℃; for 2h;	90%
With sodium hydride; ethylenediamine; In various solvent(s); at 65 ℃; for 1h;	83%
With sodium hydride; ethylenediamine; at 65 ℃; for 1h;	83%
With sodium hydride; Trimethylenediamine; at 70 ℃; for 1.5h;	83%
With sodium hydride; In ethylene-1,2-diamine; Inert atmosphere;	81%
With potassium tert-butylate; lithium; Trimethylenediamine;	80%
With potassium salt of 1,3-diaminopropane; for 1.5h; Ambient temperature; sonicated;	78%
3-heptyn-1-ol; With sodium hydride; ethylenediamine; at 45 - 60 ℃; for 1h; Inert atmosphere; With hydrogenchloride; In water; ethylenediamine; at 0 ℃; Inert atmosphere;	78%
With sodium hydride; In ethylenediamine; at 0 - 60 ℃;	72%
With sodium amide; Trimethylenediamine; at 80 ℃; for 2h;	71%
With sodium hydride; ethylenediamine; at 60 ℃;	68%
With sodium hydride; ethylenediamine; In mineral oil; at 45 - 60 ℃; Inert atmosphere;	68%
With sodium hydride; ethylenediamine; Inert atmosphere;	64%
3-heptyn-1-ol; With sodium hydride; ethylenediamine; at 20 - 65 ℃; Inert atmosphere; With hydrogenchloride; In water; for 4h; Inert atmosphere;	60%
With lithium; In Trimethylenediamine; at 40 - 60 ℃; Inert atmosphere;	48%
With lithium; Trimethylenediamine; at 40 - 60 ℃;	48%
With sodium hydride; Trimethylenediamine; In mineral oil; pentane; at 0 - 70 ℃; for 1.5h;	21%
With potassium salt of 1,3-diaminopropane; Trimethylenediamine;
With potassium salt of 1,3-diaminopropane; ammonium chloride; Yield given. Multistep reaction; 1.)1,3-diaminopropane, 4 h, R_.T_., 2.)ether, 0 deg C;
With sodium hydride; at 20 - 70 ℃; for 2h; Inert atmosphere;

: 1002-36-4
hep-2-yn-1-ol

: 63478-76-2
1-hydroxy-6-heptyne

Conditions

Conditions	Yield
With potassium hydride; 1,2-diaminopropan; In tetrahydrofuran; mineral oil; at 20 ℃; for 24h; Inert atmosphere;	99%
With potassium salt of 1,3-diaminopropane; In tetrahydrofuran; at 0 ℃; for 0.5h;	97%
With potassium tert-butylate; lithium; Trimethylenediamine; at 20 ℃; for 3h; Inert atmosphere;	90%
With potassium salt of 1,3-diaminopropane;	88%
With sodium hydride; ethylenediamine; at 60 ℃;	88%
With potassium salt of 1,3-diaminopropane;	87%
With potassium tert-butylate; lithium; ethylenediamine; for 3h;	83%
With lithium 2-aminoethylamide; In ethylenediamine; for 0.333333h; amide-hydrocarbon ratio 7:1;	82%
With potassium hydride; Trimethylenediamine; for 2h; cooling;	79%
hep-2-yn-1-ol; With potassium tert-butylate; lithium; Trimethylenediamine; at 20 ℃; for 1h; With water;	74%
With potassium salt of 1,3-diaminopropane; Trimethylenediamine;	73%
With potassium hydride; ethylenediamine; at 20 ℃;	70%
With potassium hydride; In various solvent(s); at 10 - 15 ℃; for 1.5h;	67%
With sodium hydride; ethylenediamine; at 60 - 65 ℃; for 3h;	64%
With sodium hydride; ethylenediamine; In mineral oil; at 0 - 70 ℃;	61%
With potassium hydride; Trimethylenediamine;	46%
With potassium salt of 1,3-diaminopropane; at 20 ℃; for 1h;	1.09 g

63478-76-2 Upstream products

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chloro-1 heptyne-6
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63478-76-2 Downstream products

37011-86-2
tetrahydro-2-(6-heptynyloxy)-2H-pyran
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;

63478-76-2

Quick Details

Trustworthy Factory Supply Top Purity 99% 6-Heptyn-1-ol 63478-76-2 with the Best Price

6-Heptyn-1-ol(Cas 63478-76-2) Usage

63478-76-2 Relevant articles

Polydiacetylene stabilized gold nanoparticles - extraordinary high stability and integration into a nanoelectrode device

Liffmann,Homberger,Mennicken,Karth?user,Simon

, p. 102981 - 102992 (2015)

Intramolecular silicon-assisted cross-coupling reactions: General synthesis of medium-sized rings containing a 1,3-cis-cis diene unit

Denmark, Scott E.,Yang, Shyh-Ming

, p. 2102 - 2103 (2002)

Total synthesis of two novel brominated acetylenic diols (+)-diplyne C and E: Stereoselective construction of the (E)-1-bromo-1-alkene

Gung, Benjamin W.,Gibeau, Craig,Jones, Amanda

, p. 3107 - 3114 (2005)

On the intramolecular pyrone Diels-Alder approach to basiliolide B

Kozytska, Mariya V.,Dudley, Gregory B.

, p. 2899 - 2901 (2008)

Synthesis of brombyins II and III, cyclostachines A and B, and cyclopiperstachine, plant-derived octahydronaphthalenes

Lygo, Barry,Beaumont, Douglas J.,Cooke, Jason W.B.,Hirst, David J.

, p. 618 - 622 (2010)

Directed Regioselective Carbometallation of 1,2-Dialkyl-Substituted Cyclopropenes

Cohen, Yair,Marek, Ilan

supporting information, p. 26368 - 26372 (2021/11/10)

Total Synthesis of a Mycolic Acid from Mycobacterium tuberculosis

Buter, Jeffrey,Fodran, Peter,Jayaraman, Dhineshkumar,Minnaard, Adriaan J.,Moody, D. Branch,Ocampo, Tonatiuh A.,Tahiri, Nabil,Van Rhijn, Ildiko,Witte, Martin D.

supporting information, p. 7555 - 7560 (2020/03/23)

Total Synthesis of the Tetrasubstituted Furan Fatty Acid Metabolite CeDFP via Au-Catalyzed Intermolecular Alkyne Hydroarylation

Wang, Yamin,Pritchard, Gareth J.,Kimber, Marc C.

supporting information, p. 4892 - 4895 (2019/06/27)

Synthesis and Evaluation of a Series of Bis(pentylpyridinium) Compounds as Antifungal Agents

Obando, Daniel,Koda, Yasuko,Pantarat, Namfon,Lev, Sophie,Zuo, Xiaoming,Bijosono Oei, Johanes,Widmer, Fred,Djordjevic, Julianne T.,Sorrell, Tania C.,Jolliffe, Katrina A.

, p. 1421 - 1436 (2018/07/29)

63478-76-2 Process route

63478-76-2 Upstream products

63478-76-2 Downstream products

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