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Product Details
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Description |
The side chain of ertapenem, a carbapenem antibiotic, is crucial for its pharmacological activity and pharmacokinetic properties. |
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Uses |
Ertapenem contains a substituted methylthiotetrazole group at position 1 of the beta-lactam ring, which enhances its stability against hydrolysis by beta-lactamases, enzymes produced by bacteria that can deactivate beta-lactam antibiotics. This modification contributes to ertapenem's broad spectrum of antibacterial activity against Gram-positive, Gram-negative, and anaerobic bacteria. Additionally, the side chain influences its pharmacokinetic profile, including its distribution, metabolism, and elimination from the body, thereby impacting its efficacy and safety in clinical use. |
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