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Product Details
Description |
The side chain of ertapenem contains a substituted methylthiotetrazole moiety at position 1 of the beta-lactam ring. This unique side chain is crucial for the pharmacological properties of ertapenem. |
Uses |
The methylthiotetrazole group enhances the stability of ertapenem against degradation by certain bacterial enzymes, specifically beta-lactamases. Beta-lactamases are responsible for breaking down many beta-lactam antibiotics, rendering them ineffective against bacterial infections. However, the presence of the methylthiotetrazole group in ertapenem helps to protect the beta-lactam ring from this enzymatic degradation, thereby prolonging its antimicrobial activity. This structural modification contributes significantly to the broad spectrum of activity exhibited by ertapenem against various bacterial pathogens, including both Gram-positive and Gram-negative bacteria, making it an essential therapeutic agent in the treatment of serious bacterial infections. |
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